Increased tongue use enhances 5-HT2C receptor immunostaining in hypoglossal motor nucleus
نویسندگان
چکیده
منابع مشابه
Mesopontine cholinergic projections to the hypoglossal motor nucleus.
Mesopontine cholinergic (ACh) neurons have increased discharge during wakefulness, rapid eye movement (REM) sleep, or both. Hypoglossal (12) motoneurons, which play an important role in the control of upper airway patency, are postsynaptically excited by stimulation of nicotinic receptors, whereas muscarinic receptors presynaptically inhibit inputs to 12 motoneurons. These data suggest that ACh...
متن کاملCommon synaptic input to the human hypoglossal motor nucleus.
The tongue plays a key role in various volitional and automatic functions such as swallowing, maintenance of airway patency, and speech. Precisely how hypoglossal motor neurons, which control the tongue, receive and process their often concurrent input drives is a subject of ongoing research. We investigated common synaptic input to the hypoglossal motor nucleus by measuring the coordination of...
متن کاملIncreased nicotinic receptor desensitization in hypoglossal motor neurons following chronic developmental nicotine exposure.
Neuronal nicotinic acetylcholine receptors (nAChRs) are expressed on hypoglossal motor neurons (XII MNs) that innervate muscles of the tongue. Activation of XII MN nAChRs evokes depolarizing currents, which are important for regulating the size and stiffness of the upper airway. Although data show that chronic developmental nicotine exposure (DNE) blunts cholinergic neurotransmission in the XII...
متن کاملPharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus.
State-dependent reductions in serotonin delivery to upper airway dilator motoneuron activity may contribute to sleep apnea. The functional significance of serotonin receptor subtypes implicated in excitation of dilator motor neurons was evaluated in anesthetized, paralyzed, mechanically ventilated adult rats (n = 108). The effects of antagonists selective for serotonin receptor subtypes 2A, 2C,...
متن کاملUse of an innervated tongue flap to rehabilitate the tongue after hypoglossal-to-facial nerve transfer.
Facial palsy resulting from loss of the intracranial portion of the facial nerve has been reconstructed traditionally by transferring motor axons from the hypoglossal nerve to the facial nerve.1–4 This approach can reinnervate the facial muscles if it is done before these muscles have undergone irreversible atrophy, eliminating the need for a free-muscle transfer. The two major disadvantages of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Respiratory Physiology & Neurobiology
سال: 2019
ISSN: 1569-9048
DOI: 10.1016/j.resp.2018.11.005